Precision Decisions

Disease Area:
Juvenile Idiopathic Arthritis (JIA)

Biosample Status:
Biosample Available

About the Precision Decisions Study

One of the most common forms of juvenile idiopathic arthritis (JIA) is polyarticular JIA (pJIA), which involves swelling in five or more joints. Currently, there are many different medications used to treat pJIA.

Doctors know that early and effective treatment leads to better long-term outcomes. But there are no tools that help guide doctors on when to start or stop different types of medications in children diagnosed with pJIA. The goal of Precision Decisions is to develop a simple inexpensive tool made up of a small number of individual tests. This tool will help design personalized treatment guidelines for each individual patient, which will improve outcomes and quality of life for both the patient and their family.

Researchers want to learn:

  • If there are different biological subgroups of patients among pJIA patients
  • If blood samples can help researchers create a biology-based tool to predict a patient’s response to treatment, so there is less trial and error with medications

Precision Decisions was CARRA’s first biosample collection study tied to the newest version of the CARRA Registry, so we will be able to follow the outcomes of study participants for up to 10 years later. It also builds on the first and largest study comparing early versus delayed biologic therapy in pJIA, a study called STOP-JIA.

Study Updates and Findings

This study has been completed but does not have public results at this time. Check back in a few months to see if findings have been posted.

About the Participants

  • Children participating in the STOP-JIA Study. Only children and young adults in the Start Time Optimization of Biologic Therapy in Polyarticular JIA (STOP-JIA) study through CARRA were able to give blood samples for this study.

About the Study Team

Precision Decisions is funded through a CARRA-Arthritis Foundation Large Grant.

Lead researcher:

  • Rae Yeung, MD, PhD, Toronto Hospital for Sick Children

To learn more about this project, please contact [email protected].

Related Research Projects

Disease Area:
Juvenile Idiopathic Arthritis (JIA)

CARRA Registry Research Network for SJIA-LD (CARE-NETS) Study

This project launches the first research network to collect clinical data and blood samples from children with systemic JIA and lung disease through the CARRA Registry.

Disease Area:
Juvenile Idiopathic Arthritis (JIA)

Advancing the Science of Pediatric Patient-Reported Outcomes for Children with Chronic Disease (PEPR)

Validation of patient-reported outcomes in chronic diseases.

Disease Area:
Juvenile Idiopathic Arthritis (JIA)

Disease Recapture after Drug Discontinuation and Flare in Juvenile Idiopathic Arthritis (Recapture-JIA)

Study to characterize rates and predictors of disease recapture in children with JIA who re-start medication to treat flares.