Chronic Nonbacterial Osteomyelitis (CNO) happens when the immune system attacks bones, causing inflammation without infection, and the result is intense pain and bone damage. CNO is the most common autoinflammatory bone disease but how immune system mediates the attack is unknown. It is also unclear how to best treat CNO. Early effective treatment is essential to restore bone health. Our long-term goals (NIH grant) are to identify the molecular pathways associated with CNO and determine whether some medications are as effective as others leveraging on the established multicenter CNO patient registry, “Chronic nonbacterial Osteomyelitis International Registry” (CHOIR). The bridge funding will allow us to gain group consensus on the treatment goals to precisely plan the trial and analyze initial results from blood and bone samples.