Careers

Senior Manager, Data Operations

Reports to: Senior Director of Research & Data StrategySupervises: n/aLocation: RemoteStatus: Full-time with benefits

The CARRA Registry is North America’s largest observational registry that collects clinical and patient-reported information about children and young adults with pediatric-onset rheumatic diseases. The CARRA Registry also serves as a biosample repository for translational studies that leverage data collected through the Registry.

The CARRA Registry aims to understand the long-term outcomes and long- and short-term safety and effectiveness of medications used to treat pediatric rheumatic and related autoimmune diseases. We also aim to give all affected children and families the opportunity to participate in meaningful, high-quality clinical and translational research.

General Summary

The Senior Manager / Associate Director, Data Operations provides strategic and operational leadership for data management across the CARRA Registry and Biobank. This role is responsible for ensuring the integrity, standardization, and continuity of Registry data across systems, electronic data capture (EDC) platforms, contract research organization (CRO) partners, and reporting environments.

As the primary internal data owner, this individual will drive data architecture, governance, and database strategy while leading critical migration efforts to support the transition to the Registry 2.0 operating model. This role works cross-functionally with informatics, analytics, clinical, and external partners to ensure data are reliable, accessible, and analysis-ready.

Position Responsibilities (Minimum of 37.5 hours/week)

Data Architecture & Governance

  • Own the end-to-end Registry data lifecycle, including data intake, transformation, storage, and use
  • Define and maintain data architecture frameworks to support scalability and interoperability
  • Establish and enforce metadata standards, controlled terminology, and data dictionaries
  • Develop and implement data governance processes, including data quality monitoring and issue resolution workflows
  • Serve as the internal authority on data standards and structure

Database & Migration Leadership

  • Lead database design, development, and revision strategies aligned across Registry and Biobank platforms, including EDC systems
  • Oversee data migration activities, including mapping, transformation logic, validation, and reconciliation
  • Ensure data continuity and integrity across legacy and future-state systems
  • Act as the primary day-to-day data liaison with current and future CRO partners
  • Collaborate with vendors and internal teams to manage timelines, deliverables, and issue resolution

Reporting & Analytics Support

  • Support data extraction, reporting, and dataset creation for internal stakeholders and investigators
  • Partner with analytics and data integration leadership to ensure alignment between source systems and downstream data warehouse structures
  • Enable development of analysis-ready datasets and reporting environments
  • Contribute to the design of scalable data models that support research and operational analytics

Education/Experience

Required

  • Bachelor’s degree in data science, informatics, computer science, public health, or related field (Master’s preferred for Associate Director level)
  • 5–8+ years (Senior Manager) or 8–12+ years (Associate Director) of experience in clinical data management, registry operations, or related field
  • Demonstrated experience with database design, data standards, and data governance frameworks
  • Demonstrated experience building, configuring, and maintaining electronic data capture (EDC) systems
  • Experience leading complex data migration or system transition efforts
  • Strong understanding of clinical research data workflows and multi-site data environments
  • Excellent project management and stakeholder coordination skills
  • Experience working with registries, longitudinal datasets, or real-world data
  • Familiarity with CRO oversight and vendor management
  • Knowledge of data standards (e.g., CDISC, HL7/FHIR) and interoperability concepts
  • Knowledge of common data models such as OMOP (Observational Medical Outcomes Partnership) and/or other standardized healthcare data frameworks (e.g., Sentinel, PCORnet)
  • Knowledge of CDISC standards for clinical trial data, including SDTM, ADaM, and CDASH
  • Experience supporting data warehousing and analytics environments
  • Understanding of regulatory and compliance frameworks (e.g., HIPAA, GCP)

Core Competencies

  • Strategic thinking with strong operational execution
  • Data architecture and systems mindset
  • Leadership and cross-functional collaboration
  • Data quality and governance focus
  • Problem-solving in complex, evolving environments

Expected Impact

  • Ensures high-quality, standardized, and analysis-ready data for internal teams and investigators
  • Enables a smooth transition and sustained continuity between outsourced CRO services and in-house Registry 2.0 operations
  • Establishes strong internal capabilities in data governance, architecture, and operational analytics
  • Supports scalable, future-ready data infrastructure for the Registry

Why Join Us

This is a unique opportunity to shape the data foundation of clinical research registry and biobank at a pivotal moment of transformation. You will play a central role in building modern, scalable data systems that directly support research, discovery, and improved outcomes for children with rheumatic diseases.

Compensation

Salary for this position is competitive and depends on experience. In addition, a comprehensive benefits package is included.

How to Apply

Please email your curriculum vitae and cover letter to [email protected]. Applicant review will continue until the position is filled.

Amount of Travel Required

Less than 10 days a year.