Research & Registry

Projects

Research Projects

Since CARRA’s inception, we have published numerous articles, host an annual meeting (now with almost 500 participants including more than 50 patients/parents and almost 60 workgroups), and launched major studies, including:

Projects

  • ANAStills

  • APPLE

    From preliminary observations in children and the well-described accelerated atherosclerosis and increased cardiovascular events in adults with systemic lupus erythematosus (SLE), we developed this multi-center, prospective, randomized, double-blinded interventional study of atorvastatin in children and young adults with SLE.

  • CARRA Legacy Registry

    The first registry for pediatric rheumatic diseases in the US (2010-2013)

  • CARRA Registry

    FDA-compliant enhanced registry for pediatric rheumatic diseases in the US and Canada

  • FROST

    A comparative effectiveness study of systemic JIA CTPs

  • LIMIT JIA

    A study to determine if early treatment of limited JIA with a biologic can prevent severe disease extension

  • PEPR

    The PEPR study seeks to both broaden and deepen our understanding of the social, emotional and physical functioning of children and adolescents living with chronic diseases – including pediatric onset rheumatic diseases – so that we can improve the effectiveness of treatments and the quality of life of young people affected by rheumatic diseases.

  • Phase IV Studies

    To assess the safety of medicines for JIA (currently canakinumab in systemic JIA and tocilizumab in polyarticular JIA)

  • Precision Decisions to STOP JIA

    Finding a biomarker blood test tool to be able to predict response to treatment in polyarticular JIA

  • PROMOTE

    Study assessing predictors of methotrexate response in JIA

  • RAPPORT

    A placebo controlled trial of IL-1 inhibition in systemic JIA

  • Recapture-JIA

    A study of children who have a flare of JIA after stopping their medicines for well-controlled disease

  • STOP-JIA

    A comparative effectiveness study of polyarticular JIA CTPs

  • TREAT-JIA

    Research trial assessing the effectiveness of early aggressive therapy in polyarticular JIA

Our coordinating center for almost all of these studies (including the CARRA Registry) is the Duke Clinical Research Institute (DCRI), which is located in Durham, North Carolina.

Biosample Collection

CARRA collects biosamples from study participants.

Consensus Treatment Plans

CARRA's CTP Committee provides support to investigators throughout the CTP development process. Click here to learn more!

Publications

CARRA members publish their research as soon as it becomes available. Click here to learn more!