Since CARRA’s inception, we have published numerous articles, host an annual meeting (now with almost 500 participants including more than 50 patients/parents and almost 60 workgroups), and launched major studies, including:
From preliminary observations in children and the well-described accelerated atherosclerosis and increased cardiovascular events in adults with systemic lupus erythematosus (SLE), we developed this multi-center, prospective, randomized, double-blinded interventional study of atorvastatin in children and young adults with SLE.
The first registry for pediatric rheumatic diseases in the US (2010-2013)
FDA-compliant enhanced registry for pediatric rheumatic diseases in the US and Canada
A comparative effectiveness study of systemic JIA CTPs
A study to determine if early treatment of limited JIA with a biologic can prevent severe disease extension
The PEPR study seeks to both broaden and deepen our understanding of the social, emotional and physical functioning of children and adolescents living with chronic diseases – including pediatric onset rheumatic diseases – so that we can improve the effectiveness of treatments and the quality of life of young people affected by rheumatic diseases.
Finding a biomarker blood test tool to be able to predict response to treatment in polyarticular JIA
Study assessing predictors of methotrexate response in polyarticular JIA
A placebo controlled trial of IL-1 inhibition in systemic JIA
A study of children who have a flare of JIA after stopping their medicines for well-controlled disease
A comparative effectiveness study of polyarticular JIA CTPs
Research trial assessing the effectiveness of early aggressive therapy in polyarticular JIA
Our coordinating center for almost all of these studies (including the CARRA Registry) is the Duke Clinical Research Institute (DCRI), which is located in Durham, North Carolina.
CARRA collects biosamples from study participants.
CARRA's CTP Committee provides support to investigators throughout the CTP development process. Click here to learn more.
CARRA members publish their research as soon as it becomes available. Click here to learn more!