This funding opportunity supports the development and publication of a clinical or translational project which will immediately impact research projects within CARRA or result in a larger collaborative grant that furthers the CARRA mission. New or early investigators are encouraged to apply and will be afforded special consideration. A successful application may be for:
- an all-inclusive clinical or translational research project; or
- a pilot research project, that if successful, could lead to extramural funding.
Preference will be given to submissions which are collaborative and leverage current CARRA network resources or will further develop the CARRA network.
Not currently accepting applications. The next Large Grant cycle is scheduled to open in September of 2020.
CARRA-Arthritis Foundation Large Grant Applications to Include:
- Letter of Intent (LOI)
- Project Summary/Abstract (300 word max)
- Lay Summary (150 word max)
- Resubmission Modifications, if applicable (1 page limit) (Download template: WORD)
- Resubmission modification is required if the applicant has previous submitted a similar project. Applicants should provide an explanation of what has changed from a prior application. Examples would include addressing budget differences or weaknesses the reviewers found in an earlier application.
- Specific Aims (1 page limit) (Download template: WORD)
- Research Plan (5 page limit) (Download template: WORD)
- References (no page limit) (Download template: WORD)
- Budget Table (1 page limit) (Download template: WORD)
- All Primary Investigators (PI) are required to dedicate effort on their projects which must be noted on the budget table. Requesting salary support is optional. A letter of support from your division chief documenting that the % effort is available, and confirming investigator salary (if applicable) must be submitted with each application. If the PI is the division chief, a letter from the Department Chairperson is required.
- Budget Justification (Download template: WORD)
- Total costs of salary support for PI(s) and Co-I(s) must not exceed 50% of total project costs.
- CARRA will allow up to 8% F&A (indirect) costs which must be incorporated into the project budget below. If indirect costs are requested, total costs for this project must not exceed $50,000.
- Poster printing and publication costs are not allowed.
- Travel expense requests are not permitted unless required for the conduct of research. Travel expenses to attend meetings to present this work, for example, are not allowed.
- Other expenses should be discussed with CARRA personnel prior to application submission.
- NIH-formatted Biosketches for all Principal Investigator(s), Co-Principal Investigator(s), and all Co-Investigator(s) (limit 5 pages per biosketch; please combine all biosketches into one PDF with the PI(s) biosketch listed first.)
- Letters of support
- Required for budgets that include investigator effort (include letter from division chief documenting that % effort is available, and confirming investigator salary). Total costs salary support must not exceed 50% of total project costs.
- Letters of support from collaborators, mentors and institution are highly recommended.
- Research Assurances
- Submit documentation of an Institutional Review Board (IRB) review. Funds will not be released until either 1) IRB approval letter or 2) IRB waiver/documentation that IRB has determined your project is exempt from IRB review is received.
- Appendix (limit 1 attachment)
Applicants must use the templates provided when submitting their final applications. CARRA Staff is available to assist with the application process and to answer questions. Contact us by emailing [email protected].
APPLICATIONS NOT FOLLOWING THESE INSTRUCTIONS WILL NOT BE CONSIDERED
Important Information for Large Grant Submissions
- A maximum of 2 grants will be awarded per year.
- The funding maximum limit is $50,000 total costs.
- Salary/Effort: Letters of support are required for budgets that include investigator effort (include letter from division chief documenting that % effort is available, and confirming investigator salary). Total costs salary support for the Principal Investigator(s) and Co-Investigator(s) must not exceed 50% of total project costs.
- This is a total costs award. If indirects are requested, they must be inclusive of the maximum funding amount of $50,000. Indirects may not exceed 8%.
- A given investigator can only receive one large or small grant per 365 day period.
- Funds will be provided to the awardee’s institution as a lump sum to be set up in a sundry account and used by the principal investigator according to the project budget.
- The project period is one year beginning February 15, 2020.
- A project report is required no later than 45 days after the project period end date.
- If the PI is unable to complete the project, any unexpended balance will be returned to CARRA.
- Awardees are expected to submit an abstract and attend the CARRA Annual Meeting(s) until the project is complete/final.
- If the PI is unable to complete the project, any unexpended balance will be returned to CARRA.
- Submit a one-page Letter of Intent (LOI) on institution letterhead via the online grant submission system.
- Read the CARRA-Arthritis Large Grant instructions carefully. Be sure to be compliant with formatting instructions and page limits.
- Use the document templates provided above and submit your completed CARRA-Arthritis Foundation Large Grant application by October 1 via the online grant submission system.
Letter of Intent
LOI’s are required for those submitting Large Grants and are due 30 days prior to the application deadline. The LOI should be a one-page signed letter which includes:
- A summary of the full proposal with a short description of aims of the project involved.
- Name of the PI(s) and submitting institution
- A list of key personnel and role(s)
- A description of how the project aligns with CARRA's mission.
The LOI MUST be on institutional letterhead and signed by the Principal Investigator(s).
While the LOI is an administrative requirement, it is for informational purposes only. Approval from CARRA is not needed to proceed with the full application. Investigators will receive confirmation that their LOI has been received by the CARRA grants office.
- The project PI for all grants must be a current CARRA member who is up to date on membership dues and membership information (location, contact information, and membership status) is up-to-date.
- An investigator may only receive one CARRA-Arthritis Foundation grant (transdisciplinary, large, or small) per year (365 day period).
- Awardees from previous grant cycles who wish to submit grant applications for the upcoming deadline must have all active CARRA-Arthritis Foundation grant projects completed and have submitted a final progress report (template available on the CARRA website).
- MD applicants must be at a faculty level to be eligible to submit proposals.
- Voting Members, Emeritus Members, Research Professional Member - Investigators, Research Professional Member - Research Coordinator Members, Associate Physician Members, and Trainee Members are eligible to submit proposals.
- Priority will be given to new and/or early investigators.
- All grants must be submitted by or have a pediatric rheumatologist named as a Co-Investigator.
- Research Coordinator Member- Other, Health Care Professional Members, Fellow Members, and CARRA Executive Committee and Board of Directors members are not eligible.
Funding and Funding Period
- Awards are total costs. Up to 8% F&A (indirect) costs are allowed, but costs must be incorporated into the project budget and not exceed the advertised award amount.
- Publication, presentation, and travel costs should not be requested/included, unless the travel is an essential part of performing the research. Other expenses should be discussed with CARRA personnel prior to application submission.
- Salary support will be limited to a base-salary cap of $200,000 but can include payment of local fringe rates (on top of $200,000 salary cap).
- Please review CARRA’s statement of direct and indirect support.
- All awards are for one year, with funding beginning February 15.
- Applicants will be notified of funding decisions in January 2020.
- If the project is not completed within the project period, the award recipient may request a no-cost extension (NCE) for up to 12 months. Requests for NCEs can be made up to 90 days prior, but no less than 30 days prior, to the project end date. An interim progress report must be submitted with the NCE Request Form, both of which are available on the CARRA website.
- Awardees must submit a final progress report no later than 45 days after the project period end date.
- Awardees from previous grant cycles who wish to submit grant applications for the October 2019 deadline must have all active projects completed and have submitted a final progress report (template available on the CARRA website).
- Timely provision of progress reports is taken into consideration for future eligibility for CARRA-Arthritis Foundation grants.
- Awardees are expected to submit abstracts to CARRA and present their findings at the CARRA Annual Scientific Meeting(s) until the project is complete/final.
- Awardees are expected to submit a peer-reviewed abstract to a scientific meeting based on the funded project.
- All awardees of CARRA-Arthritis Foundation funding must abide by the procedures outlined in the CARRA Publications Policy when presenting/publishing findings from their projects. This includes submitting all abstracts and manuscripts to the CARRA Publications Committee for approval prior to submission and acknowledging the support of CARRA and the Arthritis Foundation by including the following language: “The authors wish to acknowledge CARRA, and the ongoing Arthritis Foundation financial support of CARRA.” Refer to the current Publication and Presentation Guidelines for complete details.
IMPORTANT UPDATE FOR LARGE GRANT APPLICANTS USING CARRA REGISTRY DATA/SAMPLES
Grant applicants that intend to utilize the CARRA Registry or CARRA-related data and/or samples (including Legacy Registry and APPLE data/samples) must receive approval from the CARRA Data Sample Share Committee (DSSC) prior to submitting their grant applications. Applicants will be required to provide documentation of DSSC approval at the time of submitting a grant application. The request must match the intended use outlined in the grant proposal. Failure to receive approval of the data and/or sample request prior to submission of the grant application will result in the administrative decline of the application.
Data/sample requests take up to 4 weeks for review and approval. Please keep this in mind as you plan your grant application. For more information on requesting data/samples and to access the request form, please visit the CARRA Data and Samples Request area of the wiki.
If you have any questions regarding this requirement, email [email protected].
In addition, if your application will propose collection of any new data or biosamples via the CARRA Registry and/or via CARRA sites, you must include a letter of support (LOS) from CARRA's Research and Registry Oversight Committee (RROC). Email [email protected] with a brief summary of your proposal and CARRA will work to schedule a call with you to discuss your application as soon as possible.