STOP-JIA

Overview

STOPJIA (Start Time Optimization in Polyarticular Juvenile Idiopathic Arthritis) is a prospective, observational study comparing the clinical effectiveness and impact on patient reported outcomes of 3 different treatment strategies (CTPs) in new onset pJIA patients to answer the critical question of when to start biologic medications.

In STOP-JIA, patients, families, and their doctors will discuss and select one of 3 treatment plans developed and commonly used by pediatric rheumatologists which differ in the timing of when biologics are started. Patients will also contribute by answering surveys related to quality of life and burden of the disease and its treatments.

The STOP-JIA study was made possible by an award from the Patient-Centered Outcomes Research Institute (PCORI).

Leadership

Yukiko Kimura, MD

Yukiko Kimura, MD Chief, Pediatric Rheumatology Professor of Pediatrics Hackensack University Medical Center

Sarah Ringold, MD, MS Assistant Professor of Pediatrics Seattle Children’s Hospital

 


Collaborators

Patient-Centered Outcomes Research Institute
Childhood Arthritis and Rheumatology Research Alliance
Duke Clinical Research Institute
Seattle Children’s Hospital
Children’s Hospital of Philadelphia
Children’s Hospital Boston
The Hospital for Sick Children
University Health Network, Toronto

STOP-JIA Enrollment

Enrollment Update

STOP-JIA Stats:
Enrollment: 158
7 sites have enrolled 1 patient
17 sites have enrolled 2-4 patients
13 sites have enrolled 5 or more patients

Press Release 3/22/16

The Childhood Arthritis and Rheumatology Research Alliance (CARRA), Inc. announced today that the first two patients had enrolled in the Start Time Optimization in Polyarticular Juvenile Idiopathic Arthritis (STOP-JIA) project. STOP-JIA aims to answer a critical question facing patients and doctors: “When is the best time to start biologic medications in polyarticular JIA?”

JIA is the most common pediatric rheumatic condition, affecting 1 to 4 in every 1000 children. More than half of affected children have a polyarticular form affecting many joints, and suffer worse outcomes and compromised quality of life. Symptoms of JIA include, but are not limited to joint pain, swelling and stiffness.

In STOP-JIA, patients, families, and their doctors will discuss and select one of 3 treatment plans developed and commonly used by pediatric rheumatologists which differ in the timing of when biologics are started. Patients will also contribute by answering surveys related to quality of life and burden of the disease and its treatments.

The first two of an anticipated 400 patients were enrolled, from the University of Wisconsin-American Family Children’s Hospital by Anna Huttenlocher, MD, and from the Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center.

“The results of this 3-year study will be a critical step forward in defining how to treat JIA and will change clinical practice.” said Yukiko Kimura, MD, Principal Investigator, Professor, Hackensack University Medical Center.

“We look forward to sharing the results of the study which we hope will fill important knowledge gaps to enable us to make informed medication decisions for desired health outcomes for our children,” saidVincent Del Gaizo, a father of a patient with JIA, and a key member of the STOP-JIA study team. Stakeholder engagement is a major component of the STOP-JIA project.

The STOP-JIA study was made possible by an award from the Patient-Centered Outcomes Research Institute (PCORI). For video information about the study, please visit:https://www.carragroup.org/our-research/stop-jia-1 or for study details, visit:https://www.clinicaltrials.gov/ct2/show/NCT02593006?term=stop-jia&rank=1

 

STOP-JIA Prezi

The STOP-JIA Prezi was created by JIA patients and parents to help people understand what STOP-JIA is all about. Please take a look and let us know what you think by leaving comments at the bottom of this page.

You may also view the Prezi as a YouTube video here.

STOP-JIA Times Newsletter

In PDF: 1st Issue | 2nd Issue

Resources

More STOP-JIA News

Improving Enrollment

“It can be challenging to locate and enroll new patients in registry studies,” notes Pam Weiss, Site PI for the Registry at CHOP.

read more

Stop-JIA Starts

Start Time Optimization for Biologics in Polyarticular JIA, (STOP-JIA), funded by PCORI, is open for enrollment.

read more

STOP-JIA Stakeholder Advisory Panel

Patients and their caregivers are the focus of STOP-JIA. They make up a majority of the Stakeholder Advisory Panel, which oversees and gives feedback about the project and its materials. Members of the Stakeholder Advisory Panel also include a nurse, research...

read more